Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules† †Electronic supplementary information (ESI) available: Supplementary methods, gene regulatory sequences used, the characterised dose responses of the single-input Buffer gate and the three promoter inputs under various cognate chemical induction levels. See DOI: 10.1039/c4cc05264a Click here for additional data file.

نویسندگان

  • Baojun Wang
  • Martin Buck
چکیده

We designed and constructed versatile modular genetic logic gates in bacterial cells. These function as digital logic 1-input Buffer gate, 2-input and 3-input AND gates with one inverted input and integrate multiple chemical input signals in customised logic manners. Such rapidly engineered devices serve to achieve increased sensing signal selectivity.

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عنوان ژورنال:

دوره 50  شماره 

صفحات  -

تاریخ انتشار 2014